This Podcast Will Kill You

This Podcast Will Kill You

By Exactly Right

This podcast might not actually kill you, but it covers so many things that can. Each episode tackles a different disease, from its history, to its biology, and finally, how scared you need to be. Ecologists and epidemiologists Erin Welsh and Erin Allmann Updyke make infectious diseases acceptable fodder for dinner party conversation and provide the perfect cocktail recipe to match

Episodes

Ep 51 The Path of Most (Antibiotic) Resistance

No story of antibiotics would be complete without the rise of resistance. As promised in our last episode, this week we dive into what the WHO calls ‘one of the biggest threats to global health, food security, and development today’ - antibiotic resistance. In the decades since their development, misuse and overuse of antibiotics has led to many becoming all but useless, and our world seems on the verge of plunging into a post-antibiotic era. How does resistance work? Where did it come from? Why did it spread so far so rapidly? Is there any hope? In this episode, we answer all these questions and more. First, we explore the many ways bacteria evade the weaponry of antibiotic compounds. Then we trace the global spread of these resistant bugs by examining the major contributors to their misuse and overuse. And finally we assess the current global status of antibiotic resistant infections (spoiler: it’s very bad) and search for any good news (spoiler: there’s a lot!). To chat about one super cool and innovative alternative to antibiotics, we are joined by the amazing Dr. Steffanie Strathdee (Twitter: @chngin_the_wrld), Associate Dean of Global Health Sciences, Harold Simon Professor at the University of California San Diego School of Medicine and Co-Director at the Center for Innovative Phage Applications and Therapeutics. Dr. Strathdee provides a firsthand account of helping her husband, Dr. Tom Patterson, fight off a deadly superbug infection by calling on a long-forgotten method of treating bacterial infections: phage therapy.   To read more about phage therapy and Dr. Strathdee’s incredible experiences, check out The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A Memoir.
26/05/201h 50m

Ep 50 Antibiotics: We owe it all to chemistry!

Fifty episodes. That’s fifty (sometimes) deadly viruses, bacteria, protozoa, parasites, and poisons. And don’t forget the fifty quarantinis to accompany each! What better way to celebrate this momentous occasion than talking about something that may actually save you: antibiotics. In this, our golden anniversary episode, our ambition tempts us to tackle the massive world of these bacteria-fighting drugs. We explore the various ways that antibiotics duel with their bacterial enemies to deliver us from infection, and we trace their history, from the early years of Fleming and Florey to the drama-laden labs of some soil microbiologists. Finally, we end, as we always do, with discussing where we stand with antibiotics today. Dr. Jonathan Stokes (@ItsJonStokes), postdoctoral fellow in Dr. Jim Collins’ lab at MIT, joins us to talk about some of his lab’s amazing research on using machine learning to discover new antibiotics, which prompts us to repeat “that is SO COOL” and “we are truly living in the future.” We think you’ll agree.   To read more about using machine learning to uncover antibiotic compounds, head to the Collins’ lab website, the Audacious Project site, or check out Dr. Stokes’ paper:  Stokes, Jonathan M., et al. "A deep learning approach to antibiotic discovery." Cell 180.4 (2020): 688-702.
12/05/201h 59m

COVID-19 Ch 11: Modeling

The eleventh episode of our Anatomy of a Pandemic series has arrived, and just in time. Have you found yourself trying to sift through headlines claiming “this model predicts that” and “that model predicts this”, but you’re not sure where the truth really lies? Then this episode is for you. With the help of Dr. Mike Famulare from the Institute for Disease Modeling (interview recorded April 29, 2020), we walk through the basics of mathematical modeling of infectious disease, explore some of the current projections for this pandemic, and discuss some guidelines for evaluating these headline-making models. As always, we wrap up the episode by discussing the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we’ve listed the questions below: What is a math model and what are some of the goals of mathematical modeling? So talking specifically now about infectious disease models, can you walk us through what the basic components are of an infectious disease model, like an SIR model? Where do you get the data that you use to estimate the parameters in an SIR model - what is based on actual data and what has to be estimated? Infectious disease outbreaks often have a curve-like shape, with the number of infected individuals on the y-axis and time on the x-axis. Can you explain why infectious disease epidemics tend to follow a curve? Can you talk us through some of the assumptions that you have to make when you're constructing one of these models and how that kind of relates to the uncertainty inherent within models? How might that uncertainty affect interpretation? What are some examples of the various ways we use infectious disease models in public health policy? Can you talk about how models might be used at various stages of a pandemic to guide public health measures? How might our use of models early on in a pandemic be different from the middle of one? Speaking specifically about COVID-19 now, can you talk about what a basic model for this pandemic might look like?  Are models for COVID-19 using only lab-confirmed cases of the disease or clinical-confirmed cases as well? Looking back on these earlier models of COVID-19, what can we take away from the performance of these models? Is there any agreement among models as to what policies might be the best in terms of keeping cases and deaths as low as possible?  For those of us who have no background in mathematical or statistical modeling, are there guidelines that we should use to evaluate these models or compare them? What should we (as in the general public) be taking away from these models? Are there any positive changes you hope to see come out of this pandemic, either as a member of the community or as a math modeler? For a deeper dive into the wonderful world of infectious disease models, we recommend checking out this recent video from Robin Thompson, PhD of Oxford Mathematics titled “How do mathematicians model infectious disease outbreaks?” The video was posted on April 8, 2020.
04/05/201h 21m

Ep 49 Eastern Equine Encephalitis: Triple EEEk!

In 2019, eastern equine encephalitis (EEE), a viral disease transmitted by mosquitoes, made headlines in much of the US as cases skyrocketed compared to previous years. But why is this disease so feared and even more importantly, why is it on the rise? Those are just a couple of the questions we seek to answer on this week’s episode. From the nitty gritty on what this virus does to your body to centuries-long forest dynamics in Massachusetts, we connect the disease ecology dots of EEE. We promise, the biology and history of eastern equine encephalitis is much more exciting than its etymology.
28/04/201h 9m

COVID-19 Chapter 10: Schools

In the tenth episode of our Anatomy of a Pandemic series on COVID-19, we continue our exploration of the diverse impacts of this pandemic by taking a look at how education and schooling has been affected, with a particular focus on the United States. Massive school closures and transition to distance learning has revealed vast inequities in access to basic educational needs and has highlighted the importance of public schools as more than just a place to learn. We are joined by journalist Jennifer Berkshire (Twitter: @BisforBerkshire) and education historian Dr. Jack Schneider (Twitter: @Edu_Historian), producers of Have You Heard, a podcast on educational policy and politics, to examine the current challenges in delivering educational content during this pandemic and some implications for the future of public schools (interview recorded April 17, 2020). As always, we wrap up the episode by discussing the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we’ve listed the questions below: Have we seen anything like this before, like with the 1918 influenza pandemic and school closures due to polio epidemics? What are some of the services that public schools in the US provide? And how is this pandemic revealing that schools are more than just a place to learn?  Can you talk briefly about the inequalities in education and access and their historical roots? Are these inequalities unique to the United States or are there other countries where similar inequalities are seen or being revealed by this pandemic? Who is being left out in this switch to distance learning?   Can you discuss how well distance learning works across different age groups? Do you think that this epidemic will make policymakers and politicians see the economic value of schools? Or is it going to further decrease funding to schools and result in the dismantling of the public school system? How do you think our definition of school will change after this pandemic? What was the trajectory of funding for public schools before this pandemic? How well does distance learning seem to work?  When schools re-open, what kind of effects are we going to see on current students? Specifically, how do we recover when some kids will have continued to learn during this pandemic and others will likely have fallen further behind?  What positive changes do you hope to see come out of this?
23/04/201h 6m

COVID-19 Chapter 9: Economics

Episode 9 of our Anatomy of a Pandemic is here, and this week we’re stepping outside our public health sphere to examine COVID-19 from an entirely different perspective, that of an economist. Pandemics don’t happen in a vacuum, and the ripples of their impact extend far beyond those of public health, as nearly every person can attest to today. We’ve seen headlines about a global recession and high rates of unemployment, but what do those things actually mean? Have we seen something like this before or is this uncharted territory? And most importantly, what can we expect? We were curious to know the answers to these questions but we lack the expertise to take them on ourselves, so we asked economist Martha Gimbel, Manager of Economic Research at Schmidt Futures to join us on this episode about the economic impacts of COVID-19 (interview recorded April 14, 2020). A caveat: this episode focuses mostly on the economic impact of the pandemic in the US. As per usual, we wrap up the episode by discussing the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we’ve listed the questions below: What are some of the indicators that we use to know how the economy is performing, and what were the trends we were seeing in the months before this pandemic hit? Could you take us through a timeline of the economic impact, starting with the first signs that the pandemic was having an impact on the global economy? What industries felt the pandemic first, and where do we stand now? Could you break down the impact that we’re seeing on the global economy, the US economy, large corporations, small businesses, and the average consumer? Was there a global recession after the 1918 influenza pandemic? If not, what makes these current circumstances unique? Which countries or industries are the most vulnerable and why? Are certain countries or industries proving to be more resilient in the face of this global recession? Can you talk about the gig economy here and how our reliance on low-paid workers with no protection from their employers has impacted our own economic resilience? Can you talk about the implications of the numbers of unemployment insurance filings that we’re seeing and just how staggering they are? Are the current benefits offered through the unemployment system going to be enough to keep people at home and not seeking work in situations that put them at higher risks of exposure? Are there any general trends or predictions in terms of how long this recession will continue and what it will take to recover? How will we know when we have “recovered”? Are you seeing any innovative solutions that people are proposing or starting to implement in terms of a social safety net? What positive changes do you hope this pandemic will bring about? Where is the money for the stimulus checks coming from? Is that $1200 check going to be enough to keep people going for the next few months?
20/04/201h 9m

Ep 48 Botulism: Why are you the way you are?

You don’t look surprised to see this in your podcast feed - or is that just the botox? This week we’re taking a tour of the wonderful world of Clostridium botulinum and the toxin it produces, at once both poison and prescription. First, we delve into how botulinum toxin acts to paralyze your muscles and under what circumstances you might encounter it. Then we iron out the wrinkles of the why of botulinum toxin, an answer that involves migratory birds, maggots, and marshes. The story continues with blood sausages, an unfortunate funeral party, and a massive shift from toxin to treatment as the therapeutic potential of botulinum toxin is explored. And the best part of this episode? Georgia. Hardstark. You’ve heard the always amazing, ever hilarious, and one of our personal heroes Georgia Hardstark on My Favorite Murder, but now listen to her share her firsthand experience with getting botox facial injections. This episode ranks among our top favorites we've ever recorded, and we hope you love it as much as we do!
14/04/201h 27m

COVID-19 Chapter 8: Disparities

In the eighth episode in our Anatomy of a Pandemic series focusing on COVID-19, we discuss how this pandemic will likely lead to a disproportionate impact on the most vulnerable populations around the globe. “Wash your hands.” “Stay at home.” “Practice physical distancing.” These are the public health messages for how to slow this pandemic. But what happens when you can’t wash your hands because you lack clean water or soap? Or if you can’t stay at home because you’re fleeing a war zone? Dr. Jonathan Whittall, Director of Analysis at Medicines Sans Frontières (aka Doctors Without Borders) joins us to talk about the challenges faced by the most vulnerable populations during this crisis and how MSF is working to overcome those challenges while bracing for the pandemic’s impact (interview recorded April 3, 2020). We wrap up the episode by discussing the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we have listed the questions below: What kind of projects are you currently working on? Can you talk about what you're seeing in terms of the differences between this COVID-19 pandemic and other public health emergency situations, such as cholera outbreaks in refugee camps or Ebola epidemics? What are some lessons that you think hospitals in other regions can learn from physicians or logistical coordinators that have worked in these situations previously? You wrote a great opinion piece about some of the challenges faced by the most vulnerable populations in trying to prevent infection with the virus that causes COVID-19. Can you talk a bit about those challenges and what the most vulnerable populations are? What are some of the ways that MSF has been trying to overcome those challenges?  What have we seen so far in terms of the impact of COVID-19 on these vulnerable populations? MSF has recently expanded their efforts throughout Europe - can you talk about what that expansion looks like and how different groups or activities are prioritized? As a part of a group that works internationally, can you talk about some of the challenges in coordinating this work internationally and why it's so crucial to communicate across borders? There's been a lot of discussion about how this pandemic may change the way we handle public health at national and, especially, international scales. What are some of the changes you hope to see?   Follow Dr. Jonathan Whittall (@offyourrecord) or check out the MSF-Analysis website (http://msf-analysis.org/). And read his fantastic article here: https://gulfnews.com/opinion/op-eds/bracing-for-impact-of-the-coronavirus-1.70570512
09/04/2058m 40s

COVID-19 Chapter 7: Spillover

Coming at ya with our seventh episode in our Anatomy of a Pandemic series on the ongoing COVID-19 situation. So far in the series, we’ve discussed aspects of the virus’s biology, clinical disease, epidemiology, and control efforts. We’ve briefly touched on aspects of the virus’s ecology, including its origins, but we wanted to take a step back and ask, “how do spillover events happen and how do we stop them?” To answer those questions (and many more), we brought on Dr. Jonna Mazet, Professor of Epidemiology and Disease Ecology at the UC Davis School of Veterinary Medicine and Executive Director of the UC Davis One Health Institute, who has spent much of her professional life on the hunt for emerging pathogens (interview recorded April 2, 2020). We pick Dr. Mazet’s brain on how we look for and identify pathogens of possible public health concern, what work disease ecologists are currently doing on SARS-CoV-2, and what we can expect to see in terms of future spillover events. We wrap up the episode by discussing the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we have listed the questions below: Can you take us through a step-by-step of how surveillance of novel pathogens is done? From the logistics of international coordination to the sampling to the reporting - what does that look like? What happens when you do identify a potential spillover event? Can you talk about how you decide what a hotspot is? What makes a hotspot a hotspot basically? We've talked a lot on this podcast about spillover events, and obviously they can happen in many different ways, but can you give us a general overview of how one occurs? What are some patterns we see with all spillover events? Over the past 100, 200 years, land use change has increased and the barrier between humans and wildlife has decreased - have we seen a corresponding increase in spillover events during that time? What do we know at this point about how SARS-CoV-2 spilled over into humans? I assume eventually we will get a clearer picture of how that spillover event occurred. How can we use that information in the future? Can you talk about what it means for a pathogen to "jump species"? Do viruses more easily "jump species" compared to bacteria, or is it just that we hear more about the viruses? I'd like to talk about what happens when prevention has to shift to control. What are the first steps taken for disease ecologists studying this outbreak? How is the One Health approach being used to study and slow down the current COVID-19 pandemic? What role do we see wildlife conservation playing in spillover events or preventing them? Can you talk about how there can be a conflict in wildlife conservation for the greater good when people are also just trying to feed their families? How do you determine whether something easily moves between species? Is that a genomic question or is it an experimental question?  What do you think are some of the biggest barriers or challenges in identifying these spillover events in the future? The One Health approach is such a great example of interdisciplinary collaboration. Can you talk about what some of the different fields are that work in One Health? What positive changes do you hope to see come out of this pandemic? Follow Dr. Jonna Mazet (@JonnaMazet), the PREDICT project (@PREDICTproject), and the Global Virome Project (@GlobalVirome). Or check out their websites: One Health Institute (https://ohi.vetmed.ucdavis.edu/), PREDICT (http://data.predict.global/), Global Virome Project (www.globalviromeproject.org). The firsthand account was taken from a piece by Craig Spencer, MD written for the Washington Post titled, “How long will we doctors last?”
06/04/201h 1m

Ep 47 Schistosomiasis: A Snail's Pace

It’s back to your regularly scheduled programming this week with an episode on schistosomiasis (aka bilharzia), that scourge both ancient and modern. We kick off the episode by walking you through the amazingly complex life cycle of these blood flukes and the myriad of symptoms they and their eggs can cause, including a “check out the reproductive output on this one!” moment.  We then trace its early appearances in mummies (of course) and ancient writings, following that up with an overview of how imperialism drove the field of tropical medicine in its early days. To wrap up this wormy episode, we discuss the current, staggering numbers on schisto around the globe.
31/03/201h 29m

COVID-19 Chapter 6: Mental Health

Welcome to Chapter 6 of our Anatomy of a Pandemic series exploring the world of COVID-19. If you have made it this far in the series, you might be feeling a bit overwhelmed by all of the information we’re throwing your way. You’re not alone. We were feeling a bit too deep down the rabbit hole as well. So we reached out to Rosemary Walker and Peter Rosencrans, two psychology doctoral students at the University of Washington to talk to us about the mental health impacts this pandemic has had and walk us through some coping strategies (interview recorded March 20, 2020). Hang in there, everyone. To help you get a better idea of the topics covered in this episode, we have listed the questions below: You are both in Seattle, which has been impacted longer than much of the US, so, how are you? (05:55) This is a brand new situation for all of us that's affecting so much more than our physical health.So what are we seeing in terms of some of the mental health outcomes? (09:21) What are some of the challenges that you, as mental health professionals, have faced so far and that you expect to appear in the future related to COVID-19? (15:59) What are some coping strategies that we could use to deal with some of these issues? (19:15) What are some resources for people who normally see a therapist, but who cannot now because of COVID-19? (31:43) How can we as individuals be good neighbors, community members, in this stressful time while still protecting our mental health? (36:50) Do you have any specific resources that our listeners could seek out? (41:09)
23/03/2047m 25s

COVID-19 Chapter 5: Vaccines

Chapter 5 of our Anatomy of a Pandemic series covering all things COVID-19 goes through some of the exciting developments in potential vaccines for this new virus. Starting us off is an anonymous account describing the challenges faced by someone in the US trying to get tested for COVID-19. Then we review some of the basics of vaccines - how they work, the different kinds, and some of the challenges in accelerating the vaccine development pipeline during a crisis such as this. We sought the expert knowledge of Dr. M. Elena Bottazzi (interview recorded March 17, 2020), who is part of a group that is currently working on developing a vaccine for SARS-CoV-2. She answers a number of your vaccine- and treatment-related questions and sheds some light on the prospects of vaccine development for this particular disease. We wrap up again by going through the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we have listed the questions below: What makes this virus a good candidate for a vaccine? (11:05) Why is it more difficult these days to produce completely protective vaccines vs partially protective vaccines? (13:29) How is the vaccine that your group is working on made, what is its target and how does it work? (16:02) What is the timeline of vaccine development, testing, deployment, and how soon might we see an effective vaccine for SARS-CoV-2? (21:19) What steps of this development process can be shortened to get an 'early release' of a vaccine? (25:49) It seems we are better at developing vaccines than we are antivirals; why is this? (28:55)
23/03/2043m 46s

COVID-19 Chapter 4: Epidemiology

The fourth installment of our Anatomy of a Pandemic series takes a look at some of the epidemiological characteristics of the COVID-19 pandemic. But first, we hear about the experience of Katie Burson, who was quarantined along with her family on the infamous Diamond Princess cruise ship in February 2020, when cases of COVID-19 were reported among guests. Then we review some of the disease ecology of the SARS-CoV-2 spillover event and walk through a timeline of the pandemic, which, we have to admit, is pretty chilling to hear. We are joined by Dr. Carlos del Rio (interview recorded March 20, 2020), who chats with us about updated estimates for the R0 of SARS-CoV-2, reasons for regional variation in case fatality rates, and what the deal is with the slow rollout of tests in the US. We wrap up again by going through the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we have listed the questions below: Do we know what the R0 is for this virus? (27:44) Is there a risk for a second wave of infection in China or other places where the disease seems to be slowing down? (29:31) What are the stages of an epidemic curve and what does it mean to flatten that curve? (31:03) Are people who get infected able to be re-infected or are they immune? (32:45) What is the relative effect of social distancing vs herd immunity? (33:31) How can we convince people who can stay home to actually stay home? (34:40) What are the differences between populations that contribute to the differences in case fatality rate between China vs Italy vs South Korea, etc? (36:28) What might we see in terms of numbers of infections or how long the outbreak will last? What's the end game? (38:00) Should the measures that have been enacted in some parts of the US be happening even in places with fewer cases so far? (40:55) Is this virus likely to become well established and another 'seasonal' respiratory infection? (42:16) What's the deal with testing in the US? Why was rollout so slow at the beginning? (43:14) When should a person try to get tested if they suspect they're infected? (45:58) What has this outbreak taught us so far about our ability to respond to pandemics, and how can we do better moving forward? (46:36)
23/03/2059m 6s

COVID-19 Chapter 3: Control

Welcome to the third chapter of our Anatomy of a Pandemic series, in which we cover the many aspects of the COVID-19 pandemic. In this chapter, we discuss how epidemic control can be managed from the individual, state, and national levels, as well as the importance of international collaboration to prevent the uncontrolled spread of disease. We start off with a firsthand account from Dr. Colleen Kraft, featured in COVID-19 Chapter 2, who shares the challenges she faces on a daily basis during this crisis while acting as Associate Chief Medical Officer at Emory University Hospital. Then we review some of the terms you’ve probably seen all over the news lately, such as “flattening the curve” or “social distancing”. Dr. Krutika Kuppalli (interview recorded March 18, 2020) shares with us her expertise from a global health and pandemic preparedness perspective, and she answers some of your questions relating to the steps you can take to protect yourself, your loved ones, and your community. We wrap up again by going through the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we have listed the questions below: Now that community transmission is established in the US, what can we do to slow it down? (18:05) Do we need to enact these control measures (social distancing, etc.) everywhere, even in places currently have low case numbers? (19:51) Are travel bans effective in slowing disease spread? (21:20) How can we tell if our control measures are working? (22:52) How soon do we expect to see the effect of these control measures? (24:00) There have been a lot of comparisons with seasonal influenza. How does COVID-19 compare to seasonal influenza and why are we taking such extreme measures to reduce the spread of this disease when we don't do so for seasonal influenza? (25:22) How well prepared was the US for this epidemic? (28:25) What have we learned so far to help us stop the spread of this pandemic and prepare for future pandemics? (31:19) What are the risks as this pandemic spreads to less well-resourced areas? (33:39)
23/03/2054m 15s

COVID-19 Chapter 2: Disease

This marks the second installment in our Anatomy of a Pandemic series, in which we discuss the various aspects of the COVID-19 pandemic. In this second chapter, we explore what we currently know about the disease itself, from symptom progression to incubation period and the role that asymptomatic individuals play in the transmission of disease. Our firsthand account, told from the perspective of a respiratory therapist, illustrates the severity of this disease and the frightening, yet very real, prospect of running out of medical equipment, protective gear, and hospital beds. We then discuss what we currently know about COVID-19 from a clinical disease perspective. We are joined by Dr. Colleen Kraft (interview recorded March 19, 2020), whose voice you may recognize from our first episode on coronaviruses. She helps to break down some of the disease-related questions sent in by our listeners. We wrap up the episode by discussing the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we have listed the questions below: What does "respiratory droplet" transmission mean, and how is this different from something with "airborne" transmission? (15:08) What are the symptoms of COVID-19? (16:48) How long is the disease course, and how does this vary between mild vs severe symptoms? (18:45) What does "supportive care" mean in the context of caring for people who fall severely ill from COVID-19? (19:40) How much does viral load correlate with the severity of symptoms? (20:47) What is the incubation period of this disease, how long do people remain infectious, and are asymptomatic people contributing to the spread of disease? (22:22)  What are the groups that are particularly at risk for severe disease? (24:00) Why do children seem to be more resistant to this infection? What about children who are immunocompromised, are they at risk? (27:40) What is the case fatality rate, and how might we expect it to change throughout the course of this pandemic? (29:09) Are there long term complications associated with COVID-19? (31:58) Is it possible to get re-infected if you get this virus and then recover? (32:54) The full article our firsthand account came from can be found here: https://www.propublica.org/article/a-medical-worker-describes--terrifying-lung-failure-from-covid19-even-in-his-young-patients
23/03/2048m 8s

COVID-19 Chapter 1: Virology

To discuss the ongoing COVID-19 pandemic, we are introducing Anatomy of a Pandemic, a series in which each episode tackles a particular aspect of COVID-19, from virus biology to clinical disease, from control efforts to epidemiological patterns, from vaccine development to mental health coping strategies during this uncertain time. And we’ve got a quarantini (and placeborita) recipe for each installment! In the first episode of this series, we tackle some of your questions about SARS-CoV-2, the virus that is responsible for COVID-19 (aka COronaVIrus Disease-2019). Our episode begins with a firsthand account from Tiziano, a schoolteacher in northeastern Italy who has been living under the strict movement restrictions imposed by the Italian government in an attempt to limit the spread of the disease. Then, we review some of the basics about SARS-CoV-2 and RNA viruses in general. To help us discern fact from fiction, we seek the expertise of a virologist, Dr. Angela Rasmussen (interview recorded March 15, 2020), who answers some of the listener-submitted questions about the virus itself. We wrap up the episode by discussing the top five things we learned from our expert. To help you get a better idea of the topics covered in this episode, we have listed the questions below: What are the origins of this virus? Where did it come from? How can we tell whether this virus originated from one spillover event or multiple? What do we know about the mechanism of how this virus causes disease in humans? Are there multiple strains of SARS-CoV-2, and how do different strains of virus affect disease severity?  Is there a risk of SARS-CoV-2 mutating into something more deadly?  What is Remdesivir and how does it work?  How does handwashing work to reduce transmission risk? How long can SARS-CoV-2 live on surfaces?  What is the minimum infective dose of SARS-CoV-2?
23/03/2058m 21s

Ep 46 Lactose Intolerance: Never trust a fart

Everyone loves a good poop story, don’t they? We certainly hope so, because our good friend Katie shares a fantastic one to kick off our episode on lactose intolerance. In this episode, we explore what lactose is and the symptoms that lactose non-digesters experience when they eat some sneaky cheese or ice cream. Then we explain that this episode is actually flipped - turns out that not being able to digest lactose is the normal state, and those of us who can are actually the mutants! We trace the origins of this mutant allele and how the persistence of pastoralism spread milk drinking far and wide. Where do we stand with lactose intolerance today? Tune in for that answer and for an abundance of milk facts to arm yourself with for the next pub trivia night.
17/03/201h 0m

Ep 45 Hepatitis C: Hepatiti?

From its discovery only 30 years ago to the recent development of an effective treatment, the short life of the Hepatitis C virus certainly has been action-packed. This week, we take you through the biology of this deadly virus by exploring its cancer-causing qualities and pondering the plural of hepatitis. Then we take a stroll through the often bizarre and disturbing history of blood technology, discussing how a lack of sterilization and screening allowed for the proliferation of the Hepatitis C virus around the world. Finally we ask, “what’s going on in the world of Hepatitis C today?” Spoilers: it’s not all bad! As long as you can afford the treatment of course...
03/03/201h 14m

Ep 44 Pertussis: Whoop Here It Is

[TRIGGER WARNING: see below]  Whooping cough, that terrible childhood scourge, has been making an alarming comeback due to lapses in vaccination coverage across the globe. And in this episode, we’ll tell you why exactly its return is a cause for concern. From the devastation it wreaks on the body to the untold tragedy of past epidemics, pertussis is a dreaded disease that was nearly relegated to the past thanks to the amazing efforts of three incredible researchers, Pearl Kendrick, Grace Eldering, and Loney Gordon. But as the provider of our firsthand account illustrates, pertussis is still very much present today. We are joined by the incredible Catherine Hughes, who does us the honor of sharing her story about her son Riley and her efforts to raise awareness about the importance of childhood vaccinations.   Read more about the Light for Riley campaign and the Immunisation Foundation of Australia to see the hugely important work being done.   Trigger Warning: The firsthand account of this episode features the death of an infant. If you do not wish to hear this, skip to 5:10.
18/02/201h 23m

Ep 43 M-m-m-my Coronaviruses

What better time to explore the world of coronaviruses than amidst an outbreak of the 2019 novel coronavirus that brings to mind memories of SARS and MERS? On this very special episode of This Podcast Will Kill You, we’ll take you through what we know about this diverse group of viruses, from the mild strains constantly circulating to the epidemic ones that make headlines with their lethality. Want to know how exactly these royal viruses make you sick? Or what went on during the 2002-2003 SARS epidemic? Don’t worry - we’ve got you covered. And to help us get a grasp on the current 2019-nCoV outbreak that’s got the world’s attention, we’ve brought on four experts from Emory University to give us the lowdown: Dr. Colleen Kraft, Dr. G. Marshall Lyon, Dr. Aneesh Mehta, and Dr. Carlos del Rio. *Please keep in mind, we recorded this episode on Sunday, Feb 2 and conducted the interviews between Jan 29 and 30, 2020. Since recording, the statistics on 2019-nCoV that we and our guests reported have changed as the epidemic continues to evolve. The figures are changing fast, but the basic info is still relevant. To follow the 2019-nCoV outbreak, our experts recommend the following as reliable sources of information: WHO 2019-nCoV website, especially the Situation Reports Map Dashboard of 2019-nCoV Cases by Johns Hopkins Center for Systems Science and Engineering CDC 2019-nCoV website And to learn more about the amazing work that our special guests do on the regular, follow them on Twitter! Colleen S. Kraft, MD, MSc (@colleenkraftmd) G. Marshall Lyon, MD, MMSc (@GMLyon3) Aneesh K. Mehta, M.D., FIDSA, FAST (@AneeshMehtaMD) Carlos del Rio, MD (@CarlosdelRio7)
04/02/201h 48m

Ep 42 Dandy Dengue Fever

Our first vector-borne disease episode of season 3 and our first mosquito-borne pathogen in quite some time, dengue virus proves itself to be more than a worthy topic (and quite a formidable adversary in terms of public health). This week we are joined by Dr. Alex Trillo who drops some firsthand knowledge on the excruciating symptoms that give dengue its colloquial name “breakbone fever”, and then we trace the virus’s path from its evolutionary origins in ancient forests to the inevitable emergence of dengue hemorrhagic fever following modern war. We round it all out with some truly horrifying stats on the prevalence of dengue today as well as some promising research on reducing the prevalence of dengue tomorrow. To find out more about Alex’s incredibly cool research, check out her website at www.alextrillo.com and follow her on Twitter at @Trillo_PA.
21/01/201h 14m

Ep 41 Ricin: A Bad Seed

Have you missed learning about plant poisons? Well, it’s your lucky day! Today is our first crossover of season three with our friend Matt Candeias of In Defense of Plants. In this episode we delve into the castor bean plant Ricinus communis and its two notorious products: castor oil and the star of the show, ricin. Join us as we learn about ricin’s storied history, which leads us through political assassinations and efficiency in engines, the biology of ricin, which horrifies us with its lethality, and finally, the ecology of the plant, which surprises us with its strategic partnerships. Looking for more ways to cure your plant blindness? Check out In Defense of Plants at indefenseofplants.com and follow Matt on twitter @indfnsofplnts.
07/01/201h 15m

Ep 40 Dancing Plague: Worst Dance Party Ever

In 1518 a strange sight could be seen all over the town of Strasbourg. Crowds of people dancing unceasingly, unable to control their movements, seemingly heedless of their blistered and bloodied feet. As the contagious dance grew, so did the body count as the frenzied dancers succumbed to exhaustion. Over 500 years later, this dancing plague leaves us with many questions, first among them being, “What in the heck?”. In this episode, we try to get to the bottom of this mysterious infectious dance by investigating several different hypotheses, which lead us down some wild roads. Tune in, put on your best dancing shoes, and drop that beat.
24/12/191h 19m

Ep 39 Toxoplasmosis: Calling All Cats

You’ve seen the headlines: could this cat-associated parasite be controlling your every move? Is the love you have for cats pure or merely a manipulation? Join us as we discuss Toxoplasma gondii, the feline-associated parasite that infects a whopping one third of all humans. Yes, you read that right. From the behavior-altering effects on rodents to the ancestral origins of the domestic cat, we dive deep into all things toxoplasmosis, the disease that sounds like it comes straight out of a sci-fi novel.
10/12/191h 9m

Ep 38 Lead Poisoning: Heavy Metal Episode

This episode, our first foray into toxic metals, is heavy in all kinds of ways - metallically, emotionally, informationally, politically. Lead poisoning has been around for about as long humans have been working with lead, but despite its extensive history, it still poses an incredibly huge public health problem today, especially for children. Tune in to hear us chat about the multitude of effects lead exposure can have on your body, the dark and often strange history of lead poisoning (ancient Rome, anyone?), and the alarming extent to which lead exposure affects people around the world today.
26/11/191h 12m

Ep 37 E. coli (unless it's beets)

E. coli. Such a short name for such a massive topic. This episode we explore the delightful diversity of Escherichia coli, the ubiquitous bacterium that predates humans and can range in virulence anywhere from “you won’t even know I’m there” to “this is really, really, really gonna hurt”. Today we cover the good, the bad, and the ugly: you’ll hear about the innumerable contributions of E. coli to the fields of genetics, evolution, and microbiology, a detailed account of how pathogenic strains can wreak havoc on your guts, and an exploration of one of the most infamous food-borne illness outbreaks in US history. Hoping we’d end it on a happy note? Better luck next time, folks.
12/11/191h 10m

Ep 36 Shades of Syphilis

That’s right, we’re back! And we’re starting off with a bang. Syphilis, aka the Great Imitator, is the subject of today’s long-awaited episode, and it’s got everything you could imagine. When you woke up today, were you hoping to learn about how this spirochete can invade all of your body’s organs? Or how the geographic origins of syphilis are still disputed? Maybe you were wishing to gain some knowledge about a horrific experiment that revolutionized bioethics and defined what it means to give informed consent? One thing is certain - you’re definitely going to want to know about the current status of this ancient disease (yikes, it’s on the rise) and how to cure it (whew, penicillin works). Tune in to have all these wishes granted.
29/10/191h 39m

Ep 35 Lyme Disease: I'd like to check you for ticks

For our last episode of this season, we’re going out with a bang, or should we say bite? This week we’re tackling the doozy of a disease called Lyme, the most prevalent tick-borne infection in the northern hemisphere. Tune in to hear us navigate the complicated biology of Borrelia burgdoferi, delve into the ancient history of the disease (ice mummy? yes, please!), and trace the tangled ecological web woven by the spirochete, its vector, and its hosts. And to round out this delicious blood-meal of an episode, we are joined by the one-and-only hunter of ticks, ecologist of disease, and PhD advisor of Erins, Dr. Brian Allan! Not only does Brian shine some light on the current innovative research on Lyme disease ecology, but he also details his own experience with the disease. This episode is as full as a tick with information about Lyme disease, making it one you’re not going to want to miss. The clock is already ticking for our third season premiere on October 29, so mark those calendars, people! And in the meantime, wash your hands, ya filthy animals!
03/09/192h 0m

Ep 34 Cystic Fibrosis: Complete Somatic Rebellion

Despite being one of the most common genetic disorders, affecting millions of people worldwide, cystic fibrosis evaded medical description for thousands of years after its first appearance. But the last century has led to a revolution in diagnosis, treatment, and our understanding of the disease. This week we talk all things cystic fibrosis, from salty sweaty tests to European folklore, from Bell Beaker culture to gene therapy. And we are honored to be joined by Jay Gironimi, author of “Can’t Eat, Can’t Breathe, and Other Ways Cystic Fibrosis Has F#$%*d Me”, who chats candidly about his experience with CF. Oh, and the best part? Jay, also the talented musician behind All Hallow‘s Evil, wrote a custom song specifically for this episode! We loved it so much we named this ep after it, and we know you’re gonna love it too.  You can find Jay’s book on amazon in both paperback and digital versions, find the audiobook version on audible and more of his writing at canteatcantbreathe.com. You can also find his music at allhallowsevil.bandcamp.com and follow him on twitter @allhallowsevil.
20/08/191h 37m

Ep 33 Chytrid: The Silent Forest

Walking through a forest at dusk, you’ve likely heard the croaks and groans of frogs and toads forming a chorus in the damp undergrowth. But what if the forest were suddenly, inexplicably, silent? In the 1980s scientists started noticing the forests becoming quieter as amphibian populations around the globe began to decline -- rapidly. Today we are joined by Dr. Taegan McMahon from the University of Tampa to discuss our first ever wildlife disease: chytridiomycosis. Chytrid fungus, or Bd for short, has wreaked havoc on amphibian populations for the last several decades, and researchers are still trying to find a way to stop it.  For more information on Chytrid and Taegan’s research, follow her lab on instagram @mcmahon_lab. For more awesome parasitology pics, check out @uoftampa_parasitology, and for gorgeous biology art, Taegan does watercolors @wandering.ecologist!
06/08/191h 31m

Ep 32 Ask the Erins

What exactly is disease ecology anyway? How did  TPWKY come to be? How do we come up with our quarantinis? What’s our favorite pathogen? In this very special episode, you get to hear exactly what you’ve been asking for -- literally. Today we answer listener questions and don’t hold anything back. From what are the effects of climate change on vector-borne disease to what we were like at age nine, you asked and we answered!
23/07/191h 51m

Ep 31 Giardia: Gerardia

Giardia may be the most common intestinal parasite in the US and one of the most common worldwide, but did you know it was only in the last 40 years that it was officially recognized as a human pathogen?! In today’s episode, we’ll travel back to a time before humans knew microbes even existed to discover alongside Leeuwenhoek a whole new world of animalcules like giardia. We’ll find out how seeing these critters for the first time changed everything, and how long it has taken to recognize their impact on the globe. Plus, we’ll tell you all about how giardia gives you such bad poops.
09/07/191h 14m

Ep 30 Encephalitis Lethargica: Sleep Perchance to Dream (& Dream & Dream)

Imagine this: a sickness where millions fell into a deep slumber from which they never woke. Of those that did, many remained trapped in a cage of their own bodies, unable to move or speak but fully aware of the world around them. Imagine that this sickness appeared suddenly, without warning, and spread across the globe, affecting millions in just a few decades. Then, just as quickly as it emerged it disappeared. Survivors were left to suffer, eventually forgotten, while hundreds of questions remained unanswered. This is the story of encephalitis lethargica, the subject of our first ever medical mystery episode. Encephalitis lethargica was a ‘sleepy sickness’ epidemic which afflicted millions in the early 1910s and 20s but has caused only sporadic cases since the 1940s. This mysterious illness revolutionized the fields of neurology and psychiatry and forced physicians to examine where the brain ends and the mind begins. What could cause such an illness and why haven’t we seen it since? Tune in to hear us tell you the story of this fascinating medical mystery.
25/06/191h 27m

Ep 29 Aspirin the Wonder Drug: Crossover w/ IDOP

On this very special crossover episode with our friend Matt Candeias from In Defense of Plants, we’re switching things up from poison to remedy, focusing on the plant-derived wonder drug, aspirin! We cover the ancient use of salicylic acid-containing willow bark to relieve pain and fevers and then reveal how such a harsh compound was transformed into a useable pharmaceutical. We also delve into what happens in your body when you pop an aspirin and discuss why on earth so many plants make this incredible compound. Spoiler - it’s not just a wonder drug for humans.
11/06/191h 19m

Ep 28 H. pylori: Don't try this at home

This week's episode comes with a warning: don't attempt this at home. While self-experimentation has led to many a scientific breakthrough, we're definitely not advocating it. But it happened to work out for the best for Barry Marshall and Robin Warren, even earning them a Nobel prize. That’s right folks, today we’re talking about none other than Helicobacter pylori, the curvy little bacterium identified only a few decades ago to be a causative agent of peptic ulcer disease, a major risk factor in the development of gastric cancer, and a fierce warrior who can survive the harshest of environments: your stomach.
28/05/1959m 35s

Ep 27 Vaccines Part 2: Have you thanked your immune system lately?

Were you stoked about the history and biology of vaccines we covered in part 1, but left with even more questions? Were you really hoping to hear us talk about anti-vaccine sentiment and address misconceptions about vaccines in detail? Did you want even more expert guest insight?! Well then do we have the episode for you! Today, we delve into the history of the “anti-vaccine movement” which, spoiler alert, is nothing new. With the help of Dr. Peter Hotez, Dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston and Co-director of the Texas Children’s Hospital Center for Vaccine Development we address some of the most common concerns and questions that arise about vaccines, their safety, and their efficacy. And finally, we hear from Bill Nye The Science Guy about dealing with the challenges of science communication in the modern world when diseases spread as fast as fake news headlines. Y’all. This is the episode you’ve been waiting for. You can follow Dr. Peter Hotez on twitter @PeterHotez and check out his book “Vaccines Did Not Cause Rachel’s Autism” And you can listen to “Science Rules!” the new podcast from Bill Nye the Science Guy, available now on stitcher https://www.stitcher.com/podcast/stitcher/science-rules-with-bill-nye or wherever you are listening to this podcast!
21/05/192h 13m

Ep 26 Vaccines part 1: Let's hear it for Maurice

The wait is finally over: this week we are very excited to bring you the episode we’ve been teasing for weeks: vaccines! This week and next (you don’t have to wait a full two weeks for the next episode!), we are presenting a two-part series on vaccines. In today’s episode, we dive deep into the biology of vaccines, from how they stimulate your (amazing) immune system to protect you, to how they make you into an almost-superhero, shielding the innocents around you from deadly infections. We take you back hundreds, nay, thousands of years to when something akin to vaccination first began, and then we walk along the long road of vaccine development to see just how massive an impact vaccines have had on the modern world. The best part? We are joined by not one, but two experts from the Bill and Melinda Gates Foundation. Dr. Gail Rodgers and Dr. Padmini Srikantiah explain the process of vaccine development, highlight the challenges of vaccine deployment, and shine a hopeful light on the future of vaccines. And be sure to tune in next week for part 2 where we’ll focus on vaccine hesitancy and address common misconceptions surrounding vaccines in even more depth. For more information on the Bill and Melinda Gates Foundation initiatives, visit: https://www.gatesfoundation.org/ For more information on vaccines currently in development, check out: https://clinicaltrials.gov/ and https://www.who.int/immunization/research/vaccine_pipeline_tracker_spreadsheet/en/ And, as always, you can find all of the sources we used in this episode on our website: http://thispodcastwillkillyou.com/episodes/
14/05/192h 4m

Ep 25 Put your hands together for: Gonorrhea!

This bug deserves a big round of applause and not just because it’s nicknamed “The Clap”. Check out this week’s episode to gasp in wonder at the tricks that Neisseria gonorrhoeae uses to tiptoe past your immune system. Then prepare to cringe at some old-timey treatments for the disease while we trace the history of this ancient pathogen. Finally, make sure you have a quarantini or placeborita in hand for when we chat about the not-so-cheery outlook for this particular sexually-transmitted infection. Believe us, this is one episode you’re not gonn(orrhe)a want to miss.
30/04/1958m 22s

Ep 24 Zika: Rumors and Rumours

Zika virus may not have as long and storied a history as many diseases we've covered, but in a short time it has managed to make a big impression. Today we'll talk about how Zika wriggled its way out of obscurity and cover its journey from a mosquito's mouth straight to our newspaper headlines. From the first discovery of the virus in a Ugandan jungle, to the heartbreaking effects only recently discovered, to the future of Zika research and vaccine development, we'll fill you in on everything you want to know and then some.
16/04/191h 5m

Ep 23 Opening a can of Hookworms

Today we’re taking a bite out of hookworm, our first macroparasite. We start, as all hookworm journeys must, from the dewy grass, where larvae burrow into your exposed flesh and make their long and winding way to your guts, where the eggs of a fortunate few will be immortalized in fossilized poop. It’s a tale of human migration, of failed eradication, and of overburdened populations. So pull up a chair, take off your shoes, and rest your feet in the cool dew-soaked grass. But watch out for the ground itch... Find more from Meramec Valley Girl at https://meramecvalleygirl.com/ and on instagram @meramecvalleygirl
02/04/191h 11m

Ep 22 Belladonna will dilate your mind: Crossover w/ IDOP

Are you ready to dilate your mind? Or at least your eyes? We hope so, because that means you’re ready for another Poisoncast episode! This week we’re joined by our friend Matt Candeias from In Defense of Plants to chat about Atropa belladonna, a lethal yet beautiful plant that lives up to all of its many names, including deadly nightshade, belladonna, devil’s berries, and naughty man’s cherries (yes, really). We’ll explore the ancient myth, medieval lore, and modern murder that make up this plant’s history, and then we’ll venture into the nervous system to find out what belladonna has to do with fight or flight. Finally, we talk evolution to see how this deadly substance helps out its plant producer. Pour yourself a quarantini and listen up, making sure you’ve added the right berries to the mix, of course. Check out Matt’s website indefenseofplants.com and follow him on twitter @indfnsofplnts!
19/03/191h 4m

Ep 21 Measles: The Worst Souvenir

You’ve seen the recent headlines and heard the news reports, but they’re only part of this deadly virus’s story. This week we’re covering the rest. We take you on a one-of-a-kind tour of measles, exploring how this vaccine-preventable virus can wriggle its way into your cells and cause short-term misery and long-term damage. Then we trace the history of this notorious killer from its bovine beginnings to the devastation it wreaked on unexposed populations. The tour ends with a look at measles by the numbers around the world today. If you take home one souvenir from this tour, let it be gratitude for vaccines!
05/03/191h 13m

Ep 20 Prions: Apocalypse Cow

This week's episode is nothing like any of our past episodes, and there will never be another quite like it. How can we be so sure, you ask? Because this week, we're covering prions, the terrifying, genetic material-less infection that is 100% fatal and caused by nothing more than a humble protein. And not just any protein, a protein you already have in your body. Are you sweating yet? Good. Then settle in and listen to the amazing biology of this terrifying twisted proteinacious particle, the fascinating and fraught history that led to its discovery, and the current research on just how scared you need to be of prions in your brain.
19/02/191h 26m

Ep 19 Scurvy: Thanks a lot, evolution.

Arr, mateys, climb aboard for a swash-buckling tale of when the high seas were full of disease! Today we’re covering a non-infectious but no less terrifying scourge that has wrecked millions of lives and sent even the bravest of sailors quivering in their boots: Scurvy. From the open ocean to the California gold rush to modern times, scurvy has been causing collagen breakdown throughout human history, and we can blame it all on...evolution?
05/02/191h 1m

Ep 18 Hantavirus: The Real Rat Race

What do Korea, Slovenia, Finland, and the southwestern US all have in common? If you guessed Hantaviruses, you’d be quite correct. Today we bring you all the details on hantaviruses, from the deadly and terrifying hantavirus pulmonary syndrome, to the less lethal but still horrifying hemorrhagic fever with renal syndrome. From its long road to discovery, through the infamous 1993 outbreak and up to the present day, you’ll never look at an adorable little deer mouse the same way again.
22/01/191h 6m

Ep 17 Oh No Tetrodo: Crossover w/ TBOSP

Are you hungry for braaaaiiiinnnnssss? Or for fugu at the very least? We hope so, because this week we’re talking zombies and tetrodotoxin. In this crossover episode with Dr. Shane Campbell-Staton from The Biology of Superheroes Podcast, we trace the origin of the modern pop culture zombie back to its Haitian roots. We explore the outrageous evolutionary arms races in which tetrodotoxin, the principal component of so-called ‘zombie powder’, has played a major part. And finally, we answer the age-old question: can a pufferfish make you into a zombie? Be sure to check out Part 1 of this crossover episode, Episode 7 of The Biology of Superheroes Podcast, where we discuss the biological basis of death, whether we’re prepared for a zombie outbreak, and behavior-manipulating parasites. You can follow Shane @superbiopodcast on Twitter.
08/01/191h 10m

Ep 16 Scratch and Sniff Diphtheria Membrane

This episode is so good that we’re putting it out a full day early. Pour yourself a quarantini and cozy up with us as we tell you a story of a bacterium that slowly strangles children to death, a scientific quest that helped shape the understanding of infectious diseases, and a great dog sled race across wild and frozen lands to stop death in its tracks. The main character of this story is, you guessed it, Diphtheria. This dreaded disease still lingers, infecting children throughout the world today with its stinking pseudomembrane. But don't worry, it's not all bad news... we have a vaccine.
24/12/181h 1m

Ep 15 MRSA: Make Resistance Susceptible Again

We've gotten pretty graphic on this podcast before, but this episode takes it to a whole new level. The omnipresent Staphylococcus aureus is a bacterium that wears many faces. Often that face is harmless, but Staph has the power to invade and infect nearly every organ of the body, leaving destruction (and a lot of pus) in its wake. While Staphylococcus aureus has been wreaking havoc on humans since well before the discovery of antibiotics, Methicillin-resistant Staph aureus (MRSA) has risen to terrifying prominence as resistance becomes the new norm. If any disease could make you run out (or stay in) and wash your hands, it’s this one. As always, you can find all of our sources at thispodcastwillkillyou.com/episodes.
11/12/181h 8m

Ep 14 Rabies: Don't dilute me, bro

After a long hiatus we are back with a much anticipated look at one of the most feared diseases of all time: rabies. We cover everything from its evolutionary history to its massive case fatality rate, from why it makes you slobber so much to how Pliny the Elder thought you should treat it (spoiler: don't try it at home, folks). Sit back with a foam-topped quarantini in hand and enjoy our first episode of season 2.
29/11/181h 6m

Don't Tread on my Monkshood: Crossover w/ IDOP

What's the difference between a physician and a pretender, a magician and a poisoner? That's a question we'll try and answer in today's episode! We are very excited to bring you our first botanical poison crossover episode with our good friend Matt Candeias of the awesome podcast and website, In Defense of Plants. This week, we'll talk about Wolfsbane, or Monkshood, or Aconitum, or any of its various common names. The point is, get ready to learn about a pretty gnarly poison, its history, how it affects your body, and why on earth a plant would make such deadly compounds from an ecological and evolutionary perspective. Don't forget to check out our guest spot on In Defense of Plants where we talk about two plants commonly used in herbal remedies. You can find it on itunes or wherever you are listening to this pod. Check out Matt's website indefenseofplants.com  and follow him on twitter @indfnsofplnts!
29/11/181h 3m

Bonus Episode HIV/AIDS

The cherry on top of our first season, this bonus episode features more of Frank, Hillel, and Brryan's stories. Frank and Hillel, who live on opposite coasts of the US, share what it was like for them to live through through the AIDS crisis in the 1980s and 90s. Brryan and Hillel also share their experiences living with HIV today. We were incredibly moved by all three of their stories and are so honored to get to share them with you. We hope you enjoy it!  If you'd like to hear more from Brryan, you can find him on social media @BrryanJackson, and also find his website here.   If you'd like to learn more about Being Alive LA, the speaker's organization Hillel mentioned, you can find their website here.
29/11/1831m 59s

Ep 12 HIV/AIDS: Apathy Will Kill You

This is it, y'all: the season finale. This week we’re talking about HIV/AIDS, one of the biggest pandemics of modern times. We were fortunate enough to speak with three individuals who have had vastly different experiences with HIV/AIDS. Frank Iamelli, who took care of many of his friends throughout the epidemic, Hillel Wasserman, who has been living with HIV since 1987, and Brryan Jackson who was diagnosed with AIDS when he was only 5 years old. In this episode, you'll get a glimpse into their stories and then we'll fill you in on all of the biology, history, and present state of HIV in the world. Don’t forget to tune in next week for our special bonus episode where you will get to hear more of Frank, Hillel, and Brryan's stories in depth. In the meantime, here are a couple of links to Brryan's website and Being Alive LA which you'll hear more about next week!
29/11/181h 29m

Ep 11 Ebola: The New Kid on the Block

Let's face it. This is the episode you've been waiting for. Are you ready for one of the most publicized epidemics of the century? Because we're ready to tell you about it. Ebola has been in the scientific consciousness since 1976, but why did it take an outbreak of epic proportions for you, dear listeners, to hear about it? Well, listen closely for the answer. Special guests this episode include badass scientists Lauren Cowley, Nell Bond, and Sarah Paige, who will share their first-hand experiences with the 2014 Ebola epidemic.
29/11/181h 1m

Ep 10 Yellow Fever: Is there a Hamilton song about this?

Today we're talking about yellow fever, a disease with a history as colorful as its name, and a vector as pretty as a picture (depending on whom you ask, I suppose). From an epidemic that decimated Memphis, Tennessee in the late 1800s, to the development of the vaccine, to where the offending mosquito hangs out today, we'll cover everything you need to know about this disease. Like for example did you know that A. Ham The Man himself was infected?! Yeah, me neither. Let's learn things together.
29/11/1858m 5s

Ep 9 Tuberculosis: A Slow Burn

Today, we’re taking a page straight out of Dickens and talking about tuberculosis- a disease as rich in history as it is in bloody sputum. We'll travel the path of an individual Mycobacterium tuberculosis as it makes it way down the respiratory tract of its victim and waits patiently, hidden and untouchable. We’ll learn why Nicole Kidman's skinny physique was so en vogue in Moulin Rouge, talk about ‘The Royal Touch’, which isn’t quite as creepy as it sounds, cover enough of Koch's postulates that you can give yourself an honorary microbiology degree, and oh so much more.
29/11/1859m 0s

Ep 8 ABRACADABRA - Go Away Malaria!

It's both a disease of dinosaurs and a plague of people. A gin and tonic might make you forget how much those bites itch, but it won't protect you much from this mosquito-borne monster. That's right people, today we're talking about malaria! We're super excited to tell you about this parasite since it's one of EAU's personal favs (are we allowed to have favorite horrible diseases?). Come along as we travel back millions of years to explore malaria's wee beginnings, trace its path as it shaped human evolution, take a short botanical detour to make that G & T, and end up where we first began--in 2017. Turns out that monster hasn't released humanity from its clutches quite yet.
29/11/1859m 45s

Ep 7 Hit Me With Your Best (Polio) Shot

A scientific rivalry for the ages, a president with a closely kept secret, and a summertime with no pool time. What do all these things have in common? Well step right up and take a listen- today we're talking about polio, that virus that just won't quit.
29/11/181h 1m

Ep 6 Plague Part 2: TGFA

We're back with another episode all about plague-TGFA: Thank Goodness For Antibiotics! Today we'll focus on the status of plague in the modern world: where it is, where it isn't, and what we can do about it. And as always, we'll let you know whether or not to put on your scaredy pants.
29/11/1840m 25s

Ep 5 Plague Part 1: The GMOAT

That's right y'all... Today we're talking the GMOAT: The GREATEST MORTALITY OF ALL TIME: BLACK DEATH. This episode we'll cover the biology and history of one of the most epic diseases of all time- Yersinia pestis the causative agent of plague. It's such an epic topic in fact, that you'll have to tune in next week to catch up on the current status of plague around the world!
29/11/1859m 45s

Ep 4 The Poop Show

That's right.. this is the poop show! Today we talk cholera- the bacterial disease that makes you liquid-poop your pants (and then some). Travel back in time with us to when London was a sewage-filled cesspool until the Original John Snow stepped in to save the day and created the field of epidemiology. But is cholera a thing of the past? Not so much.
29/11/1849m 41s

Ep 3 Gnarlypox

This week we pay tribute to one of the gnarliest diseases of all time, and the only human disease that's ever been eradicated (thus far). That's right, people- we're talking smallpox! It's gonna get grody. Smallpox has a depressing history, a fascinating biology, a moderately uplifting present, and a precarious future. We'll cover it all.
29/11/1857m 58s

Ep 2 Skin in the Game, Horse in the Race

This week we tackle leprosy. That biblical (or is it?) infection that, believe it or not, is still with us today. Leprosy has an ancient history that exemplifies some of the worst of human behavior, and its present day status may surprise you.
29/11/1854m 19s

Ep 1 Influenza Will Kill You

In Episode 1 we're talking all things flu, just in time for the start of flu season! We'll dive into the 1918 influenza pandemic that killed literally millions of people, then talk about the state of influenza in the world today, and tell you everything you need to know about how the flu virus works.
29/11/1856m 28s

Episode 0 - TPWKY Season 1 Trailer

Welcome to This Podcast Will Kill You, your new favorite way to learn about disease biology, history, and stuff to gross out your dinner party guests. Join us October 31st for Episode 1 of Season 1- "The Plagues You Know"!
29/11/181m 23s
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